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Structural comparison of the classical and non-canonical IκB kinases (IKKs). The kinase domain of IKKε exhibits 27% and 24% identity to IKKα and IKKβ, respectively, and TBK1 shares 49% identity and 65% similarity to IKKε. ULD, ubiquitin-like domain; LZ, leucine zipper; HLH, helix-loop-helix; NB, NEMO-binding domain.
