Table 6.
Multivariable Cox regression analysis for overall survival.
| Variable | Entire Cohort (n = 7565) Overall Survival (OS) |
Case Control Cohort (n = 1802) Overall Survival (OS) |
||||
|---|---|---|---|---|---|---|
| Hazard Ratio HR |
95% CI | p-Value | Hazard Ratio HR |
95% CI | p-Value | |
| Local therapy | 0.011 | 0.004 | ||||
| BCS + RT | 1 | 1 | ||||
| Mastectomy | 1.268 | 1.055–1.525 | 1.452 | 1.124–1.875 | ||
| Age at diagnosis | <0.001 | <0.001 | ||||
| <40 years | 1 | 1 | ||||
| 40–49 years | 1.011 | 0.674–1.517 | 0.439 | 0.240–0.804 | ||
| 50–59 years | 1.273 | 0.870–1.861 | 0.599 | 0.346–1.038 | ||
| 60–69 years | 1.757 | 1.203–2.565 | 0.854 | 0.494–1.476 | ||
| ≥70 years | 4.552 | 3.089–6.710 | 2.335 | 1.342–4.065 | ||
| Tumor stage | <0.001 | <0.001 | ||||
| T1N0 | 1 | 1 | ||||
| T2N0 | 1.763 | 1.446–2.150 | 1.633 | 1.175–2.270 | ||
| T1N1 | 1.529 | 1.214–1.925 | 1.375 | 0.887–2.130 | ||
| T2N1 | 2.892 | 2.337–3.580 | 2.589 | 1.786–3.753 | ||
| Resection status | 0.608 | 0.712 | ||||
| R0 | 1 | 1 | ||||
| R1/R2 | 1.144 | 0.685–1.911 | 1.184 | 0.484–2.896 | ||
| Grade | <0.001 | 0.033 | ||||
| G1 | 1 | 1 | ||||
| G2 | 1.406 | 1.100–1.798 | 1.968 | 1.028–3.768 | ||
| G3 | 2.165 | 1.645–2.848 | 2.432 | 1.227–4.820 | ||
| Hormone receptor | 0.076 | 0.606 | ||||
| positive | 1 | 1 | ||||
| negative | 1.254 | 0.986–1.612 | 1.135 | 0.702–1.834 | ||
| Chemotherapy | 0.481 | 0.708 | ||||
| yes | 1 | 1 | ||||
| no | 1.075 | 0.880–1.313 | 1.075 | 0.736–1.570 | ||
| Endocrine therapy | 0.662 | 0.709 | ||||
| yes | 1 | 1 | ||||
| no | 1.039 | 0.876–1.232 | 0.946 | 0.708–1.26 | ||