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. 2019 Feb 1;8(2):170. doi: 10.3390/jcm8020170

Figure 2.

Figure 2

OsseoShaper-produced osteotomies retain more viable bone chips and osseous coagulum. Gross view of a hole produced in 0.32 g/cc Sawbone prepared with (A) a conventional drilling protocol versus (C) OsseoShaper. Representative transverse sections stained with aniline blue in the osteotomy sites using (B) a conventional drilling protocol and (D) OsseoShaper protocol. Micro-CT imaging of an osteotomy prepared with (E) a conventional drilling protocol versus (G) an OsseoShaper. (F) Quantification of bone chips in the osteotomy by µCT imaging (N = 5). Representative tissue sections of bone chips produced by the OsseoShaper using (H) 4′,6-diamidino-2-phenylindole (DAPI) and (I) phalloidin staining. Intra-operative view of an osteotomy prepared with conventional drills versus the OsseoShaper in rats (J,M), in mini-pigs (K,N), and in patients (L,O). Arrows indicate the osteotomy. Small arrows in (D) indicate the osteoid matrix. Dotted lines show the edge of the osteotomy. Asterisk indicates p < 0.05. Scale bars = 1 mm (A,C,J–O) and 200 μm (B,E). Abbreviations: as indicated previously.