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. 2019 Feb 1;8(2):170. doi: 10.3390/jcm8020170

Figure 4.

Figure 4

OsseoShaper drilling protocol promotes alveolar bone healing. Representative transverse tissue sections stained with aniline blue on post-osteotomy day 3 (POD3) following osteotomy site preparation with (A) conventional drills versus (B) the Nobel OsseoShaper. Note the presence of osseous coagulum in the osteotomy site prepared with the OsseoShaper. Adjacent tissue sections immunostained with Cathepsin K in the osteotomy sites of (C) conventional drills versus (D) the Nobel OsseoShaper. (E) Quantification of Cathepsin K+ve pixels/total pixels in the osteotomy site. Adjacent tissue sections immunostained with Osterix in the osteotomy sites of (F) conventional drills versus (G) the OsseoShaper. (H) Tissue sections stained with aniline blue show minimal new bone formation in conventional drill group, while (I) osteotomies in the OsseoShaper group show more new bone formation on POD7. (J) Quantification of aniline blue+ve pixels/total pixels in the osteotomy site. Dotted lines show the edge of the osteotomy. One asterisk indicates p < 0.05. Two asterisks indicate p < 0.01. Scale bars = 100 μm. Abbreviations: as indicated previously.