Figure 3.

Selective killing of tumor cells under glucose starvation by QNZ and papaverine. (A) The viability of four tumor cell lines treated with QNZ (100 nM) or papaverine (3 µM) for 48 h under glucose starvation and normal conditions was determined using crystal violet staining. * p < 0.05. (B). Cell death of cells treated with the indicated compounds for 24 h in normal or glucose-starved medium was measured by annexin V/ Propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS). Typical FACS plots obtained using MCF7 cells are shown. Data represent mean ± SD; * p < 0.05; n ≥ 3 independent experiments.