Figure 5.
Effect of AQPs absence on the distensibility of the cerebral ventricular system. (A) Representative in vivo records of the increment of intraventricular pressure (ΔP) obtained after 1.75 μL of volume increase [produced by 15 seconds (t1 − t0) of aCSF infusion after increase the flow rate from 7 to 14 μL/min) on wt, AQP1−/−, AQP4−/− and double-AQP−/− KO mice. (B) Quantitative analysis of the ΔP in the experimental groups described before. The ventricular compliance (C) is inversely proportional to ΔP: such as C = V/ΔP. Data are presented as mean ± S.E.M. The number of animals analyzed per experimental condition is indicated in parenthesis in the figure. * p < 0.05; ** p < 0.01; *** p < 0.001.