Table 2.

Effects of cytochalasans on mammalian cells and against biofilms of Staphylococcus aureus. Actin disruption: +++ complete disruption at 1 µg/mL, ++ complete disruption at 5 µg/mL, + incomplete disruption at 5 µg/mL, - no disruption; Reversibility: + reversible effect, +/- partially reversible effect, - irreversible; nd: not determined because it was not active in the first place. Anti-Biofilm activity: activities taken from the study by Yuyama et al. [8]; nt: compound not tested, due to insufficient amounts available or apparent instability.

	Trivial Name	Actin Disruption	Reversible	Anti-Biofilm [8]	Biological source
1	Fragiformin C	+	+/-	nd	Hypoxylon fragiforme (this study)
2	Fragiformin D	+++	-	nd	H. fragiforme (this study)
3	Saccalasin A	-	nt	+	Daldinia sacchari [12]
4	Cytochalasin B	++	+	-	Preussia similis (this study)
5	Deoxaphomin	+++	-	+	P. similis (this study)
6	Cytochalasin D	+++	+/-	-	Zygosporium mansorii (Sigma)
7	Cytochalasin F	+	+	nd	P. similis (this study)
8	Cytochalasin H	+++	+	-	H. fragiforme [8]
9	L-696,474	+++	+	++	H. fragiforme [8]
10	21-O-Deacyl-L-696,474	+++	+	+	H. fragiforme [8]
11	Cytochalasin Z2	+	+	nd	P. similis (this study)
12	“Cytochalasin 6” [16]	+++	-	+++	D. eschscholtzii [8]
13	“Cytochalasin 9” [16]	++	-	-	D. eschscholtzii [8]
14	“Cytochalasin 10” [17]	+	+/-	+++	D. eschscholtzii [8]
15	“Cytochalasin 11” [17]}	+	+/-	+++	D. eschscholtzii [8]
16	“Cytochalasin 12” [18]	-	nt	+	D. eschscholtzii [8]
17	New Cytochalasin	+	+/-	nd	D. eschscholtzii [8]
18	19,20-Epoxycytochalasin C	+++	+	++	Rosellinia rickii [8]
19	19,20-Epoxycytochalasin D	+++	+/-	-	R. rickii [8]
20	19,20-Epoxycytochalasin N	+	+	-	R. rickii [8]
21	18-Deoxy-19,20-Epoxy-cytochalasin Q	++	+	-	R. rickii [8]
22	Phenochalasin C	++	-	+	H./D. kretzschmarioides [8]
23	Phenochalasin D	-	nt	++	H./D. kretzschmarioides [8]
24	Chaetoglobosin A	+	+	+++	Ijuhya vitellina [13]
25	Chaetoglobosin D	++	-	nd	Il. vitellina [13]