Table 3.
Respiratory and hemodynamic parameters.
| Day 1 | Day 3 | Day 7 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | LRM Group | Control Group | p Value | LRM Group | Control Group | p Value | LRM Group | Control Group | P Value |
| No. of patients | 60 | 60 | 57 | 55 | 35 | 37 | |||
| Tidal volume, mean (SD) a, | 7.7 (1.0) | 7.6 (0.9) | 0.57 | 7.8 (1.2) | 7.6 (1.0) | 0.49 | 7.9 (1.3) | 7.8 (1.5) | 0.62 |
| mL/kg of ideal body weight | |||||||||
| Total respiratory rate, mean (SD) a | 21 (4) | 22 (5) | 0.11 | 20 (4) | 21 (5) | 0.14 | 20 (5) | 22 (6) | 0.11 |
| Plateau pressure, mean (SD) a | 25.3 (3.9) | 25.7 (4.6) | 0.73 | 24.0 (4.7) | 26.1 (4.3) | 0.07 | 25.2 (5.7) | 26.2 (4.4) | 0.74 |
| Cdyn, median (IQR) a | 28.2 (25.8–36.3) | 25.3 (21.5–28.5) | 0.001 | 31.0 (27.0–36.2) | 26.7 (20.9–30.7) | 0.001 | 32 (28.3–38.0) | 26.5 (26.0–31.0) | 0.002 |
| FiO2, median (IQR) a | 0.50 (0.47–0.62) | 0.55 (0.47–0.72) | 0.37 | 0.38 (0.35–0.46) | 0.45 (0.40–0.55) | 0.005 | 0.35 (0.30–0.40) | 0.40 (0.35–0.49) | 0.04 |
| Set PEEP, mean (SD) a | 13 (3) | 12 (3) | 0.19 | 11 (4) | 11 (3) | 0.24 | 10 (5) | 9 (3) | 0.47 |
| pH, mean (SD) a | 7.40 (0.07) | 7.34 (0.33) | 0.71 | 7.43 (0.06) | 7.43 (0.06) | 0.42 | 7.46 (0.07) | 7.46 (0.06) | 0.74 |
| PaCO2, mean (SD) a | 35.7 (6.1) | 36.1 (9.2) | 0.70 | 35.8 (6.3) | 37.0 (5.6) | 0.23 | 37.3 (6.7) | 36.5 (6.5) | 0.85 |
| PaO2, mean (SD) a | 92.1 (28.2) | 84.0 (28.8) | 0.06 | 82.9 (13.9) | 79.3 (12.3) | 0.19 | 80.6 (16.5) | 80.3 (22.5) | 0.40 |
| PaO2/FiO2, mean (SD) a | 174.8 (67.8) | 150.8 (62.8) | 0.047 | 209.7 (72.7) | 174.1 (55.1) | 0.004 | 222.7 (69.7) | 200.3 (71.3) | 0.21 |
| Heart rate, mean (SD) | 98 (21) | 99 (20) | 0.65 | 89 (17) | 93 (18) | 0.14 | 94 (20) | 96 (17) | 0.47 |
| Systemic blood pressure, mean (SD) | 133 (20) | 119 (20) | <0.001 | 136 (17) | 130 (23) | 0.09 | 137.7 (22.6) | 136.8 (28) | 0.92 |
| Diastolic blood pressure, mean (SD) | 70 (12) | 65 (11) | 0.03 | 72 (11) | 69 (12) | 0.10 | 74.6 (18.3) | 73.0 (14.7) | 0.88 |
SD standard deviation, IQR interquartile range, Cdyn dynamic compliance, FiO2 fraction of inspired oxygen, PEEP positive end-expiratory pressure, PaO2 partial pressure of arterial oxygen, PaCO2 partial pressure of arterial carbon dioxide; a Data shown were derived from the average value obtained for each patient over 3 measurements each day; values were recorded on days 1, 3, and 7 after enrolment.