Figure 5.

Combination of paclitaxel and Dasatinib treatment regimen in mice reduces tumour burden compared to control group but not to paclitaxel treated group and inhibits the paclitaxel-induced p-Src expression in tumours. (A) Tumour burden represented as collective tumour weights, 30 days post transplantation of cells and 12 days post treatment. (B) Representative images of p- or t-Src staining in HEY cell derived xenografts. Magnification 200× scale bar = 200 µM. Quantification of (C) p-Src and (D) t-Src, DAB staining was performed using Fiji software. Results are displayed as average DAB staining of the same samples (×10,000) ± SD. Significance is indicated by * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.