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. 2019 Feb 19;11(2):243. doi: 10.3390/cancers11020243

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Dasatinib treatment reduces tumour invasion into organs and reduces infiltration of macrophages in tumours. (A) Histological analysis of liver, pancreas and intestines showing tumour attachment/invasion, post 12 days of treatment. Magnification 200× scale bar = 200 µM. (B) Immunohistochemical staining of F4/80 macrophage marker in liver lesions and omental tumours. Magnification 200× scale bar = 200 µM. (C) Quantification of F4/80 DAB staining in omental tumours using Fiji software. Results are displayed as number of positive cells ± SD. Significance between the groups and is indicated by ***p < 0.001, **** p < 0.0001.