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. 2019 Feb 3;11(2):177. doi: 10.3390/cancers11020177

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DFX suppressed tumorigenicity and expression of stemness markers in miPS cells in vivo. (A) miPS cells (5 × 10⁵ per mouse) treated with 0.2% DMSO or 50 μM DFX were implanted subcutaneously into the right flank, and tumorigenicity was evaluated. DFX significantly suppressed the tumor volume of miPS cells in vivo. * p < 0.05. (B) DFX significantly suppressed the tumor weight of miPS cells in vivo. * p < 0.05. Macroscopic images show that tumors in the DFX group were smaller than those in the control group. (C) Harvested tumors were analyzed for expression of stemness markers (Nanog, Sox2, Oct/4, Klf4, c-Myc) by immunohistochemistry, and evaluation of the stemness marker area index was calculated with Image J software. * p < 0.05, ** p = 0.09. Most stemness markers, except Oct3/4, were significantly suppressed in the DFX group.

DFX suppressed tumorigenicity and expression of stemness markers in miPS cells in vivo. (A) miPS cells (5 × 10⁵ per mouse) treated with 0.2% DMSO or 50 μM DFX were implanted subcutaneously into the right flank, and tumorigenicity was evaluated. DFX significantly suppressed the tumor volume of miPS cells in vivo. * p < 0.05. (B) DFX significantly suppressed the tumor weight of miPS cells in vivo. * p < 0.05. Macroscopic images show that tumors in the DFX group were smaller than those in the control group. (C) Harvested tumors were analyzed for expression of stemness markers (Nanog, Sox2, Oct/4, Klf4, c-Myc) by immunohistochemistry, and evaluation of the stemness marker area index was calculated with Image J software. * p < 0.05, ** p = 0.09. Most stemness markers, except Oct3/4, were significantly suppressed in the DFX group.