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. 2019 Feb 1;11(2):167. doi: 10.3390/cancers11020167

Figure 2.

Figure 2

Model of the effect of the Ras/Erk vs. the PI3k/Akt pathways. mT binds to, activates and is phosphorylated by Src family kinases. The mT-pY250 site binds the Shc adaptor which triggers activation of the Ras/Erk pathway, leading to GJIC suppression. The mT-pY315 site binds the p85 regulatory subunit of PI3k, triggering activation of Akt, leading to GJIC increase. Upon wt-mT expression the Ras pathway prevails with elimination of communication as a result. Interestingly, neoplastic transformation by mT requires both pathways. Not shown: mT-pY322 activates PLCγ and PKC, which suppresses GJIC.