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Model on PI3k and Stat3, apoptosis and GJIC. A number of oncogenes (Onc) activate the transcription factor E2F family, through a number of steps [111]. E2F, in turn, can induce apoptosis through p53-dependent and independent pathways. Interestingly, the oncogene also activates PI3k and Stat3 which block apoptosis, so that neoplastic transformation can occur. Upon PI3k and Stat3 inhibition however, apoptosis will suppress GJIC.
