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. 2019 Jan 30;11(2):157. doi: 10.3390/cancers11020157

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Identification of genes specific to single melanoma tumour cells that are also up-regulated in MCSP- and ABCB5-enriched CTC fractions. (A) Pivot plot comparing gene expression profiles of single tumour cells and nonmalignant cells, from publicly available data [31], identified 847 genes that are specifically expressed by single tumour cells (red triangle) and 196 genes specifically expressed by single nonmalignant cells (black triangle). Comparison of these tumour-specific genes against the genes found to be up-regulated in MCSP (B) and ABCB5 CTC fractions (C) identified, respectively, 11 and 10 genes that are commonly expressed by single melanoma tumours as well as by MCSP or ABCB5 CTC fractions.