Table 2.
Enriched cellular hallmarks in MCSP CTC fractions from metastatic melanoma cases.
| Gene Set Name (Hallmark) | Number of Genes in Overlap | k/K | p-Value | FDR q-Value | Overlapped Genes |
|---|---|---|---|---|---|
| TNFA_SIGNALING_VIA_NFKB | 20 | 0.1 | 3 × 10−21 | 1.5 × 10−19 | IL1B, NAMPT, NFKBIA, TNFAIP6, ABCA1, TNFAIP3, G0S2, TRIB1, NFIL3, SLC2A3, IRS2, SOCS3, GADD45B, SAT1, PLK2, BCL6, NR4A2, CCNL1, BCL2A1, B4GALT5 |
| INFLAMMATORY_RESPONSE | 16 | 0.08 | 1.1 × 10−15 | 2.8 × 10−14 | IL1B, NAMPT, NFKBIA, TNFAIP6, ABCA1, RAF1, ADM, HIF1A, CSF3R, AQP9, IL18RAP, MEFV, SLC31A2, FAR2, KCNJ2, PROK2 |
| KRAS_SIGNALING_UP | 9 | 0.045 | 3.3 × 10−7 | 5.5 × 10−6 | IL1B, TNFAIP3, G0S2, TRIB1, CSF2RA, ARG1, LY96, CLEC4A, TLR8 |
| COMPLEMENT | 8 | 0.04 | 3.6 × 10−6 | 3.0 × 10−5 | TNFAIP3, RAF1, PLSCR1, CDA, CR1, F5, GCA, ITGAM |
| HYPOXIA | 8 | 0.04 | 3.6 × 10−6 | 3.0 × 10−5 | TNFAIP3, NFIL3, SLC2A3, ADM, IRS2, DDIT3, EXT1, FOXO3 |
| INTERFERON_GAMMA_RESPONSE | 8 | 0.04 | 3.6 × 10−6 | 3.0 × 10−5 | NAMPT, NFKBIA, TNFAIP6, TNFAIP3, HIF1A, EIF4E3, PLSCR1, SOCS3 |
| IL2_STAT5_SIGNALING | 7 | 0.035 | 3.5 × 10−5 | 2.2 × 10−4 | NFIL3, SLC2A3, GADD45B, PLSCR1, IL1R2, NFKBIZ, WLS |
| MTORC1_SIGNALING | 7 | 0.035 | 3.5 × 10−5 | 2.2 × 10−4 | NAMPT, NFIL3, SLC2A3, DDIT3, IDI1, FAM129A, IFRD1 |
| IL6_JAK_STAT3_SIGNALING | 5 | 0.0575 | 4.6 × 10−5 | 2.6 × 10−4 | IL1B, SOCS3, CSF3R, CSF2RA, IL1R2 |
| BILE_ACID_METABOLISM | 5 | 0.0446 | 1.5 × 10−4 | 7.7 × 10−4 | ABCA1, AQP9, IDI1, ACSL1, SULT1B1 |