Table 3.
Enriched cellular hallmarks in ABCB5 CTC fractions from metastatic melanoma cases.
| Gene Set Name (Hallmark) | Number of Genes in Overlap | k/K | p-Value | FDR q-Value | Overlapped Genes |
|---|---|---|---|---|---|
| EPITHELIAL_MESENCHYMAL_TRANSITION | 8 | 0.04 | 4.7 × 10−7 | 2.3 × 10−5 | VCAN, MYL9, PLOD2, LRP1, THBS1, FGF2, PTX3, CALU |
| APICAL_JUNCTION | 7 | 0.035 | 6 × 10−6 | 1 × 10−6 | VCAN, MYL9, INSIG1, ADAM9, SRC, VCL, RRAS |
| HEME_METABOLISM | 7 | 0.035 | 6 × 10−6 | 1 × 10−6 | H1F0, ENDOD1, BLVRA, CTNS, HEBP1, MARCH2, SNCA |
| ANDROGEN_RESPONSE | 4 | 0.04 | 4 × 10−4 | 4.5 × 10−3 | INSIG1, H1F0, GUCY1A3, ABCC4 |
| ESTROGEN_RESPONSE_EARLY | 5 | 0.025 | 6.3 × 10−4 | 4.5 × 10−3 | ENDOD1, KLF10, MYOF, AMFR, ZNF185 |
| KRAS_SIGNALING_UP0 | 5 | 0.025 | 6.3 × 10−4 | 4.5 × 10−3 | GUCY1A3, TSPAN13, YRDC, EPB41L3, MMD |
| MTORC1_SIGNALING | 5 | 0.025 | 6.3 × 10−4 | 4.5 × 10−3 | PLOD2, INSIG1, DDIT3, STARD4, MLLT11 |
| COAGULATION | 4 | 0.029 | 1.3 × 10−3 | 8.1 × 10−3 | LRP1, THBS1, ADAM9, SERPING1 |
| COMPLEMENT | 4 | 0.02 | 4.9 × 10−3 | 2.7 × 10−2 | LRP1, ADAM9, SRC, SERPING1 |
| PI3K_AKT_MTOR_SIGNALING | 3 | 0.029 | 5.6 × 10−3 | 2.7 × 10−9 | DDIT3, DUSP3, MAP2K6 |