Table 8.
Comparisons of characteristics of patients with iron deficiency in the CKD cohort.
| Variable | Patients with Iron Deficiency (n = 107) | Patients without Iron Deficiency (n = 290) | P Value |
|---|---|---|---|
| Age (years) | 107 | 290 | 0.002 †† |
| 0–2 years | 16 (15.0) | 18 (6.2) | |
| 2–6 years | 25 (23.4) | 42 (14.5) | |
| 6–12 years | 30 (28.0) | 85 (29.3) | |
| 12–17 years | 36 (33.6) | 145 (50.0) | |
| Sex (male/female) | 68/39 | 205/85 | 0.173 †† |
| Disease preceding CKD | 95 | 254 | 0.017 †† |
| Glomerulonephritis | 12 (12.6) | 62 (24.4) | |
| Non-glomerulonephritis | 83 (87.3) | 192 (75.6) | |
| CKD stages | 107 | 290 | 0.057 †† |
| I | 23 (21.5) | 46 (15.9) | |
| II | 28 (26.2) | 75 (25.9) | |
| IIIa ※ | 26 (24.3) | 46 (15.9) | |
| IIIb ※ | 15 (14.0) | 50 (17.2) | |
| IV | 14 (13.1) | 57 (20.0) | |
| V | 1 (1.0) | 16 (5.5) | |
| Weight (kg) | 105 | 285 | 0.213 †† |
| Low weight | 33 (30.8) | 76 (26.7) | |
| Normal | 66 (61.7) | 201 (70.5) | |
| Overweight | 6 (5.6) | 8 (2.8) | |
| Height (cm) | 105 | 285 | 0.835 † |
| Short stature | 25 (23.8) | 61 (21.4) | |
| Normal | 78 74.3) | 219 (76.8) | |
| Tall stature | 2 (1.9) | 5 (1.8) | |
| Hypertension | 91 | 251 | |
| SBP hypertension | 20 (22.2) | 32 (12.7) | 0.036 †† |
| DBP hypertension | 16 (17.6) | 60 (23.9) | 0.214 †† |
| Comorbidity | 107 | 290 | 0.009 †† |
| Present | 71 (66.4) | 150 (51.7) | |
| Absent | 36 (33.6) | 140 (48.3) | |
| Iron supplementation treatment | 107 | 289 | 0.692 †† |
| Yes ** | 21 (19.6) | 62 (21.5) |
Numerical values are reported as n (%); CKD, chronic kidney disease; n, number of patients; EPO, erythropoietin; SBP, systolic blood pressure; DBP, diastolic blood pressure; ※ CKD stage III is divided into subgroup stage IIIa and IIIb according to the eGFR (estimated glomerular filtration rate), stage IIIa is an eGFR between 45 and 59 and Stage 3b is an eGFR between 30 and 44; ** Iron agents: Any agent including intravenous or oral intake; † Statistically significant differences were demonstrated using Fisher’s exact test; †† Statistical significance was demonstrated using the Chi-square test.