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. 2019 Feb 2;8(2):115. doi: 10.3390/cells8020115

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Current model of Cln3 function in Dictyostelium. (1) Cln3 localizes primarily to the contractile vacuole (CV) system, and to a smaller extent, compartments of the endocytic pathway and the Golgi complex. (2) Cln3 function is linked to mitosis. (3) Loss of cln3 increases the rate of cell proliferation, alters cytokinesis, decreases the efficiency of regulatory volume decrease (RVD), reduces adhesion, delays aggregation, causes cells to develop precociously, and impairs spore integrity. (4) Loss of cln3 reduces the intracellular level of CsaA protein. (5) Loss of cln3 increases the expression of tpp1A during osmotic stress and increases TPP1 enzymatic activity. (6) Cln3 modulates the secretion of AprA and CfaD. (7) Loss of cln3 increases the secretion of Tpp1F, Cln5, CtsD, CadA, and selected cysteine proteases. (8) Loss of cln3 reduces the secretion of CMF during growth.