Table 1.

The NCCN BRCA testing criteria (NCCN Guidelines Version 2.2019).

Breast Cancer Diagnosed ≤ 45 Years

OC, fallopian tube or primary peritoneal cancer at any age.

Male breast cancer.

Triple negative BC diagnosed ≤ 60 years.

BC diagnosed 46–50 years with a second BC primary at any age.

BC diagnosed 46–50 years with ≥ 1 close relative with BC or prostate cancer (GS ≥ 7) or with unknown or limited family history.

BC diagnosed at any age with ≥ 1 close relative with BC ≤ 50 years or OC or male BC or metastatic prostate cancer or pancreatic cancer.

BC diagnosed at any age with ≥ 2 additional diagnosis of BC at any age in patient and/or in close blood relatives.

Personal history of BC or prostate cancer (GS ≥ 7) with Ashkenazi Jewish ancestry.

Pancreatic cancer.

Metastatic prostate cancer.

Prostate cancer (GS ≥ 7) at any age with ≥1 close blood relative with OC at any age or pancreatic cancer or metastatic prostate cancer or BC ≤ 50 years.

Prostate cancer (GS ≥ 7) at any age with ≥ 2 close blood relatives with BC or prostate cancer (any grade).

BRCA 1/2 pathogenic/likely pathogenic mutation detected by tumor profiling of any tumor type in the absence of germline pathogenic/likely pathogenic variant analysis.

Regardless of family history, some individuals with a BRCA-related cancer may benefit from genetic testing to determinate eligibility for targeted treatment.

An individual who does not meet the other criteria but with ≥ 1 first- or second-degree blood relative meeting any of the above criteria. The significant limitations of interpreting test results for an unaffected individual should be discussed.

BC: Breast Cancer; OC: ovarian cancer; GS: Gleason Score; Close blood relatives include first-, second- and third- degree relatives on same side of family.