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Comparison between the Nefmut and the wild type Nef functions.
| Nef Function | Nefmut [68,69] | Wild-Type(wt)-Nef [70,71,72,73,74,75] |
|---|---|---|
| CD4 down-regulation | − | +++ |
| Increase of HIV-1 (Human Immunodeficiency Virus 1) infectivity | − | +++ |
| Class I MHC (Major Histocompatibility Complex) down regulation | − | ++ |
| PAK (p21-activated kinase) activation | − | +++ |
| NAK (NF-kappaB-activating kinase) activation | − | +++ |
| Exosome association | +++ | +/− |
