Table 3.

Strengths of the Nef^mut-based CTL vaccine platform.

Strengths of the Nefmut-Based CTL Vaccine Platform
In vivo, endogenously engineering of exosomes with high therapeutic efficacy.
Overcoming the pitfalls of ex vivo or in vitro exosome production and isolation approaches.
Specificity of the immune response for the antigen of interest, with low risk of an immunogenic response to endogenously engineered exosomes.
Advantages in terms of development, production, costs, and safety compared to other exosome-based approaches.
Impact of the data obtained from the breast cancer HER2/Neu model of primary carcinogenesis.