Table 2.

Types and number of CNS adverse effects for the included studies.

Number	Author, Year	Total Sample Size	Propranolol (n)	Comparison (n)	Type of CNS Effect	Number Patients with CNS Effect in
						Propranolol Group	Control Group
1	Abrazua-Araya, 2014	25	10	13	Adverse event related to CNS	0	0
2	Kim, 2017	35	17	16	Growth disability	0	2
3	Leaute-Labreze, 2013	16	7	7	Drowsiness	1	0
4	Malik, 2013	22	10	10	Somnolence	1	0
5	Gong, 2015	28	13	13	Lethargy	2	0
6	Bauman, 2014	21	11	8	Growth and development	0	8
7	Hogeling, 2011	39	19	20	Sleep disturbances	2	2
8	Leaute-Labreze, 2015	456	401	55	Sleep disorder	83	7
		456	401	55	Agitation	45	6
		456	401	55	Somnolence	12	1
9	Tan, M., 2012	69	33	36	Adverse event related to CNS	0	0
10	Zhong S, 2015	42	21	21	Adverse event related to CNS	0	0
11	Jin, YJ, 2011	75	43	32	Adverse event related to CNS	0	0