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. 2019 Jan 23;11(2):135. doi: 10.3390/cancers11020135

Figure 8.

Figure 8

Effect of E4031 on intracellular Ca2+ in PANC-1 cells cultured onto FN (circles) or DM plus Hypo-PSC-CM (squares). [Ca2+]i was determined by Fura2 fluorescence intensity as detailed in Materials and Methods in the absence (CTR) or in the presence of 40 µM E4031 (E4031). At least 25 cells per condition from 3 independent experiments were analyzed. Data are reported as Ca2+ ratio at λ340/λ380. Data are mean ± SEM. Average values of PANC-1 in control versus E4031 conditions on FN are significantly different: p < 0.0001. Average values of PANC-1 in control versus E4031 conditions on DM plus Hypo-PSC-CM are significantly different: p < 0.0001. Average values of PANC-1 in control conditions on FN versus DM plus Hypo-PSC-CM are significantly different: p < 0.0001. p values were determined by ANOVA test (significant level set to p < 0.05).