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Induction of telerogenic DCs by Treg cells. A number of different factors/signals delivered by Treg cells might function in concert to convert immunogenic DCs into tolerogenic DCs. In addition to cell-cell interactions via membrane receptors, Treg cells can produce IL-10 and TGF-β, which inhibit the function of DCs and therefore the generation of effector T cells (see text). TCR: T cell receptor, LAG-3: lymphocyte activation gene 3, IL-10: interleukin 10.
