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. 2019 Jan 22;11(2):127. doi: 10.3390/cancers11020127

Figure 3.

Figure 3

Forced expression of NICD reversed the inhibitory effect of TRIB3 knockdown in radioresistant TNBC cells. 231-RR cells were transfected with control vector (VC) or NICD plasmid (NICD) for 24 h followed by lentiviral transduction of TRIB3 specific shRNAs (KD1 or KD2) or sh-LacZ (Ctrl) for 48 h. (A) Cells performed mammosphere cultivation and formed mammospheres were counted at day 7. ** p < 0.01; * p < 0.05 when compared with the VC/Ctrl group. (B) Cells were seeded in 6 well-plates and received irradiation of 2 or 4 Gy. After 1-week cultivation, the formed colonies were stained by crystal violet and counted by Image J software. * p < 0.05; ** p < 0.01 when compared with VC groups of the same irradiation dosage.