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. 2019 Jan 24;11(2):137. doi: 10.3390/cancers11020137

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CD200R1-related genes are associated with shorter overall survival in humans. (A) Transcriptome profile for glioblastoma showing clusters of genes associated with overall survival were analyzed in patient tumor samples available in The Cancer Genome Atlas database. Transcripts with increased levels are shown in yellow, while transcripts with decreased levels are shown in blue. Transcript level clusters with correlation >0.60 and containing ≥60 genes were systematically identified using Gene Cluster Expression Summary Scores. These clusters are visualized with a numbered black bar to the right of each of the heatmaps. Those with significant differences in survival based on Kaplan–Meier analyses are indicated with symbols and their associated p-values are shown. (B–D) Kaplan–Meier plots showing that patients expressing high levels of the gene cluster containing CD200 (red lines) had shorter overall survival times than those expressing lower levels (black lines). Comparisons are top quartile (Q1) versus three lowest quartiles (Q234), top two quartiles (Q12) versus the lowest two (Q34), and top three quartiles (Q123) versus the lowest (Q4).