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. 2019 Jan 28;8(2):94. doi: 10.3390/cells8020094

Figure 3.

Figure 3

Expression of TSPO in cuprizone-intoxicated mice. The representative results of the anti-TSPO immunohistochemistry demonstrating the expression of TSPO in perivascular astrocytes (arrow in A), oligodendrocyte progenitor cells (B), glia cells beneath the pial surface of the cortex (C), ependymal cells lining the lateral ventricles (D), choroid plexus cells (E) and interfascicular oligodendrocytes in the corpus callosum (arrows in F). (G) Schematic illustration of the investigated regions. (H–K) The representative results of the anti-TSPO immunohistochemistry in the control or cuprizone-intoxicated mice. (L) A high-power view of an anti-TSPO+ astrocyte (arrows) in the corpus callosum of cuprizone-intoxicated mice. (M) The densitometric quantification of the anti-TSPO staining intensity in different brain areas. (N) The quantification of anti-TSPO+ cell densities in the somatosensory cortex of control and 5-week cuprizone-intoxicated mice, with representative pictures shown in (J) and (K). mCC (medial part of the corpus callosum); Cx (cortex); CP (choroid plexus). Differences between the groups were statistically tested using two-tailed t-test. Welsh correction was applied for the medial corpus callosum. * p  <  0.05, ** p  <  0.01, and *** p  <  0.001.