Figure 2.

Schematic overview of the (A) PASS and (B) GAPP meta-analyses outcome in pheochromocytoma (PCC) and abdominal paraganglioma (PGL). Each tumor sample is represented by a square, in which green color indicates a benign tumor as according to the definition by each study. Orange squares denote cases defined as malignant. The left column of each classification system signifies number of cases with low algorithm scores, whereas the right column contains cases with scores ≥4 (PASS) and ≥3 (GAPP). As demonstrated here, both algorithms exhibit excellent sensitivity but reduced specificity towards malignant cases. These analyses indicate that low PASS and GAPP scores almost always are associated with a benign clinical course.