Table 1.

List of genes and proteins regulated by both ERα and p53.

Metabolic Targets of p53	Regulation by p53	p53 Status ∗	Regulation by ERα	p53 Status ∗	References
G6PD	Repression	wt	Activation	wt	[135,136]
SREBP1	Repression	wt	Activation	wt	[136]
			Repression	wt	[135]
PFK1(PFKM)	Repression	wt	Repression	wt	[135]
			Activation	wt	[137]
PGM1	Repression	wt	Repression	wt	[136,138]
PDK2	Repression	wt	Repression	wt	[135]
PCK1	Repression	wt	Activation	wt, R280K	[139,140]
HK2	Repression/Activation	G103S, E256G	Repression	wt	[141,142]
			Activation	wt	[136,138,143]
GLUT1(SLC2A1)	Repression	wt	Repression	wt	[136,142,144]
			Activation	wt, R280K, E285K	[135,138,140,143,145,146,147]
GLUT4(SLC2A4)	Repression	wt	Activation	wt	[135,148]
ME1	Repression	wt	Repression	wt, L194F, E285K	[135,138,149]
			Activation	wt	[136,139,141]
ME2	Repression	wt	Repression	wt	[136]
			Activation	wt	[138]
TIGAR	Activation	wt	Activation	wt, L194F, E285K	[149]
PARK2	Activation	wt	Repression	wt	[150]
SCO2	Activation	wt	Activation	wt	[144]
			Repression	wt	[138]
LPIN1	Activation	wt	Activation	wt	[150]
CPT1C	Activation	wt	Repression	wt	[136]
GLS2	Activation	wt	Repression	wt	[135]
MCD (MLYCD)	Activation	wt	Repression	wt	[136]

^∗ p53 status of cell lines used to determine the ability of p53 and ER to regulate the metabolic enzymes listed in the table. wt: wild-type.