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. 2019 Jan 23;8(2):83. doi: 10.3390/cells8020083

Figure 2.

Figure 2

High passenger strand dysregulation compared to the guide strand dysregulation in VSMCs and in vivo. The graphs show the percentage of dysregulated miRNAs for each form in the three independent models. (A) The relative dysregulation of each strand of the miRNA hairpin was quantified after stimulation by platelet-derived growth factor (PDGF) and IL-1α in human VSMCs (the statistics have been made between the passenger and guide strands within each condition; unpaired t-test; ** p < 0.01 for passenger vs guide strands). The heat map illustrates the relative dysregulation (in relative quotient (RQ)) of a number of miRNA hairpins after stimulation by PDGF and IL-1α across three independent patient samples (average of n = 3). (B) The dysregulation of the guide and passenger strands was quantified at 7 days following stenting (BMS (bare-metal stent) or DES (drug eluting stent)) or at 7 days following vein grafting in vivo (n = 6 for both the porcine models, except for the 7 days in the DES condition where n = 5) (the statistics have been made between the passenger and guide strands within each condition; unpaired t-test; * p < 0.05 and ** p < 0.01; and vs. the corresponding control (unstented control animals or saphenous), # p < 0.05 and ### p < 0.001).