Table 4.
Incidence and hazard ratio of mortality compared among PTE patients with different number of AED (anti-epileptic drug) use and compared to PTN.
| Variables | n | Event | Person-Years | Rate | Crude HR (95% CI) |
Adjusted HR a (95% CI) |
Crude HR (95% CI) |
Adjusted HR a (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Posttraumatic nonepilepsy | 1425 | 252 | 9126 | 27.6 | 1(Reference) | 1(Reference) | ||
| Posttraumatic epilepsy | ||||||||
| Without antiepileptic drug | 42 | 5 | 289 | 17.3 | 0.63 (0.26, 1.55) | 0.83 (0.34, 2.01) | 1 (Reference) | 1 (Reference) |
| One antiepileptic drug | 219 | 68 | 1433 | 47.4 | 1.73 (1.32, 2.26) *** | 2.05 (1.56, 2.69) *** | 2.70 (1.09, 6.69) * | 2.48 (0.99, 6.18) |
| Two antiepileptic drugs | 515 | 198 | 2846 | 69.6 | 2.48 (2.06, 2.99) *** | 2.28 (1.87, 2.78) *** | 3.85 (1.58, 9.34) ** | 2.89 (1.18, 7.07) * |
| More than two antiepileptic drugs | 649 | 263 | 2870 | 91.6 | 3.13 (2.63, 3.72) *** | 2.63 (2.17, 3.19) *** | 4.78 (1.97, 11.6) *** | 3.30 (1.35, 8.08) ** |
Rate: Per 1000 person-years; HR: Relative hazard ratio; a Adjusted for age, sex, alcohol-related illness, anxiety, mental disorders, insomnia, depression, stroke, COPD, CAD, diabetes, hypertension, and hyperlipidemia; * p < 0.05, ** p < 0.01, *** p < 0.001. Antiepilepsy drug including potassium clorazepate, phenobarbital, diazepam, zonisamide, valproic acid, topiramate, tiagabine, pregabalin, oxcarbazepine, levetiracetam, lamotrigine, gabapentin, carbamazepine, phenytoin, clonazepam, and primidone.