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. 2019 Feb 2;8(2):32. doi: 10.3390/antiox8020032

Figure 5.

Figure 5

Scheme showing that inhibition of DLDH could activate the Nrf2 signaling pathway, resulting in upregulation of antioxidant enzymes including NAD(P)H quinone dehydrogenase 1 (NQO1) and heme-oxygenase-1 as well as other antioxidant enzymes.