Table 1.
Patient ID | Age | Gender | Definitive Treatment Modality | Additional Local Therapy Prior to Enrollment | Size (mm) | T Stage ***** | DecisionDx UM Class | Days Elapsed *** | Number of Cycles of Ipilimumab | Ipilimumab Dose (mg/kg) | Baseline LDH (ULN 618 IU/L) | Reason for Discontinuation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 35 | M | Brachytherapy | Yes, thermotherapy | 16 × 15 × 8 | 3 | 2 | 204 | 7 | 3 | 386 | Completed Therapy |
2 | 45 | M | Brachytherapy | - | 12 × 10 × 3 | 1 | 2 | 63 | 5 | 3 | 421 | 4th induction dose and last maintenance dose held due to Grade 3 transaminitis and Grade 2 fatigue and hypothyroidism |
3 | 58 | F | Brachytherapy * | Yes, avastin | 15 × 12 × 4 | 2 | 2 | 77 | 6 | 3 | 523 | 3rd induction dose held due to Grade 3 rash |
4 | 74 | F | Brachytherapy | - | 13 × 13 × 4.6 | 2 | 2 | 161 | 7 | 10 | 552 | Completed therapy |
5 | 60 | M | Proton beam therapy | - | 21 × 17 × 10.1 | 4 | 2 | 111 | 2 | 10 | 402 | Only 2 doses given due to Grade 4 vasculitis |
6 | 59 | F | Brachytherapy | Yes, avastin | 13 × 10 × 4.4 | 2 | 2 | 317 | 2 | 10 | 428 | Only 2 doses given due to Grade 3 diarrhea, Transaminitis |
7 | 65 | M | Enucleation | - | 14 × 12 × 11 | 3 | 2 | 83 | 7 | 10 | 357 | Completed therapy |
8 | 50 | F | Brachytherapy | - | 6 × 5 | N/A | 2 | 179 | 6 | 10 | 287 | 3rd induction dose held secondary to Grade 3 hypophysitis |
9 | 57 | M | Brachytherapy | ** | 8 × 8.1 × 2.7 | 1 | 2 | 67 | 5 | 10 | 417 | 4th induction dose held secondary to Grade 2 hypophysitis; last maintenance dose held due to Grade 3 transaminitis |
10 | 58 | M | Enucleation | - | 15 × 14 × 9 | 3 | 2 | 153 | 7 | 10 | 592 **** | Completed therapy |
* In combination with cryotherapy and radiation; ** received intraocular avastin prior to diagnosis of uveal melanoma; *** from definitive therapy to initiation of ipilimumab; **** LDH obtained after initiation of therapy; ***** all tumors located within the choroid and/or ciliary body.