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. 2019 Feb 25;9(2):80. doi: 10.3390/biom9020080

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Cortically anchored ternary complex control spindle positioning in animal cells. Working model of spindle positioning in C. elegans embryo (A) and human cells (B). The ternary complex (LIN-5/GPR-1/2/Gα in C. elegans and NuMA/LGN/Gαi) is anchored below the cell cortex and recruits dynein motor protein complex. Dynein being a minus-end-directed microtubule-dependent motor complex attempts to move towards the centrosomes (shown by light brown arrow), but since it is anchored it instead pulls the astral microtubules resulting in the generation of the pulling forces towards the cell cortex (shown in black arrow). Please see text for more details.