Table 2.

miRNAs significantly associated with DLBCL subtype in more than two studies.

Significant miRNAs	Result	n GCB	n ABC	Sample Source	Method	n miRNAs	Reference
miR-155-5p	Down GCB	53	95	FFPE	qRT-PCR	8	Go et al. 2015 [26]
		32	27	FFPE	qRT-PCR/array	377	Iqbal et al. 2015 [38]
		20	34	FF and FFPE	qRT-PCR/array	177	Caramuta et al. 2013 [28]
		36	31	FF	qRT-PCR	1	Huang et al. 2012 [44]
		21	69	FFPE	qRT-PCR	2	Zhong et al. 2012 [30]
		32	28	FFPE	Array	464	Lawrie et al. 2009 [41]
		16	18	FF and FFPE	qRT-PCR	3	Lawrie et al. 2007 [33]
		4	19	FF	Semiq. RT-PCR	1	Eis et al. 2005 [34]
		41	30	FF	sequencing	miRNAome	Lim et al. 2015 [27]
	NA	25	25	FFPE	qRT-PCR	157	Roehle et al. 2008 [32]
miR-221-3p	Down GCB	11	18	FFPE	qRT-PCR/array	470	Montes-Moreno et al. 2011 [45]
		32	28	FFPE	Array	464	Lawrie et al. 2009 [41]
		16	18	FF and FFPE	qRT-PCR	3	Lawrie et al. 2007 [33]
		41	30	FF	sequencing	miRNAome	Lim et al. 2015 [27]
	NS	20	20	Tissue	Array	113	Zhang et al. 2009 [43]
		20	34	FF and FFPE	qRT-PCR/array	177	Caramuta et al. 2013 [28]
miR-222-3p	Down GCB	11	18	FFPE	qRT-PCR/array	470	Montes-Moreno et al. 2011 [45]
		32	28	FFPE	Array	464	Lawrie et al. 2009 [41]
		41	30	FF	sequencing	miRNAome	Lim et al. 2015 [27]
	NS	25	25	FFPE	qRT-PCR	157	Roehle et al. 2008 [32]
		20	20	Tissue	Array	113	Zhang et al. 2009 [43]
		32	27	FFPE	qRT-PCR/array	377	Iqbal et al. 2015 [38]
		20	34	FF and FFPE	qRT-PCR/array	177	Caramuta et al. 2013 [28]
miR-146a-5p	Down GCB	20	34	FF and FFPE	qRT-PCR/array	177	Caramuta et al. 2013 [28]
		21	69	FFPE	qRT-PCR	2	Zhong et al. 2012 [30]
	NS	41	30	FF	sequencing	miRNAome	Lim et al. 2015 [27]
		20	20	Tissue	Array	113	Zhang et al. 2009 [43]
miR-146b-5p	Down GCB	32	28	FFPE	Array	464	Lawrie et al. 2009 [41]
	NS	32	27	FFPE	qRT-PCR/array	377	Iqbal et al. 2015 [38]
		41	30	FF	sequencing	miRNAome	Lim et al. 2015 [27]
		20	20	Tissue	Array	113	Zhang et al. 2009 [43]
		47	59	FFPE	qRT-PCR	2	Wu et al. 2014 [21]
		20	34	FF and FFPE	qRT-PCR/array	177	Caramuta et al. 2013 [28]
miR-28-5p	Up GCB	11	18	FFPE	qRT-PCR/array	470	Montes-Moreno et al. 2011 [45]
		32	27	FFPE	qRT-PCR/array	377	Iqbal et al. 2015 [38]
		41	30	FF	sequencing	miRNAome	Lim et al. 2015 [27]
		20	20	Tissue	Array	113	Zhang et al. 2009 [43]
	NS	20	34	FF and FFPE	qRT-PCR/array	177	Caramuta et al. 2013 [28]
		32	28	FFPE	Array	464	Lawrie et al. 2009 [41]

GCB: Germinal center B-cell like; FF: fresh frozen; FFPE: formalin-fixed paraffin-embedded; NA: not available; Up: statistically significantly upregulated in the subtype of DLBCL patients; NS: no significant difference between patient subtypes; Down: significantly downregulated in the subtype of DLBCL patients.