Table 3.

Relationship between white matter changes and the severity of Alzheimer’s disease.

	AD N = 501
	Total Patients	Very Mild Dementia CDR 0.5	Mild Dementia CDR 1	Moderate Dementia CDR 2	p Value
Fazekas scale (Periventricular)	1.5 ± 1.1	1.3 ± 1.1	1.5 ± 1.1	1.9 ± 1.1	0.001 *
Fazekas scale (Deep white matter)	1.0 ± 1.2	0.8 ± 1.1	1.0 ± 1.2	1.2 ± 1.3	0.067
ARWMC, total score	6.2 ± 5.8	5.1 ± 5.7	6.1 ± 5.6	8.2 ± 5.9	0.000 *
Frontal, score	2.6 ± 2.2	2.2 ± 2.2	2.6 ± 2.1	3.5 ± 2.2	0.000 *
Parieto-occipital, score	2.5 ± 2.3	2.1 ± 2.3	2.5 ± 2.2	3.3 ± 2.3	0.000 *
Temporal, score	0.8 ± 1.9	0.7 ± 1.8	0.8 ± 1.8	1.0 ± 2.1	0.515
Basal Ganglia, score	0.3 ± 0.7	0.2 ± 0.5	0.3 ± 0.7	0.4 ± 0.7	0.065
Infratentorial, score	0.0 ± 0.2	0.0 ± 0.1	0.0 ± 0.2	0.0 ± 0.3	0.359

MMSE = Mini-Metal Status Examination; CDR = Clinical Dementia Rating; ARWMC = Age-Related White Matter Changes. * Statistical significance was expressed by p value < 0.05.