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. 2019 Feb 10;11(2):202. doi: 10.3390/cancers11020202

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of SYK decreases the cell viability of neuroblastoma cells. Cell viability was measured in SH-SY5Y and SK-N-BE(2) cells by MTT assay after 48 h incubation with increasing concentrations of the SYK inhibitors BAY 61-3606 (A) R406 (B) PRT062607 (C) GS-9973 (D). The control was set as 100% viable cells. Data are presented as mean ± SD from three independent experiments. Using two-way ANOVA, a significant difference between cell lines and a significant effect of the inhibitor p < 0.001 was seen. Dunnett’s multiple comparison test was used to evaluate the difference between vehicle treated control cells and the various inhibitor concentrations: * p < 0.05 ** p < 0.01 *** p < 0.001.