Figure 5.

Next generation sequencing data suggesting ORAI3 silencing reduces the expression of genes associated with cell migratory and inflammatory/immune responses. Networks of genes associated with biological functions (nodes) that were significantly altered with ORAI3 siRNA-mediated silencing after hypoxia (1% O₂, 72 h), identified using Ingenuity Pathways Analysis. Suppressed biological functions are represented in blue nodes. Only biological functions with a z-score below −2.3 are shown (refer to Table S1). No processes were augmented. Biological functions related to a same category were manually circled and labelled with cell migration or inflammatory/immune responses.