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. 2019 Feb 18;11(2):237. doi: 10.3390/cancers11020237

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Endothelial Cx-dependent regulation of cell migration in angiogenesis. Gap junctions and Cxs regulate cell migration via channel function dependent and independent pathways. (a) Extracellular ATP released by Cx-hemichannels activates P2Y receptors, which trigger cell migration [48]. (b) Gap junction-mediated propagation of calcium waves is required for collective cell migration. (c) The interaction of Cx and gap junction with cytoskeletal proteins or intracellular proteins orchestrates cytoskeletal rearrangement and cell migration [24,116].