Table 1.
Demographics and characteristics a.
| Phenotype Characteristic | Stable (20 samples) |
BOS (20 samples) |
RAS (20 samples) |
|---|---|---|---|
| Recipient | |||
| • Recipient age, year (SD) | 46 (14) | 51 (15) | 44 (16) |
| • Recipient male/female, % | 35 | 40 | 50 |
| Donor | |||
| • Donor age, year (SD) | 39 (15) | 47 (14) | 46 (13) |
| • Donor male/female, % | 40 | 45 | 50 |
| Indication for lung transplantation, % | |||
| • Emphysema | 35 | 35 | 5 |
| • COPD | 0 | 15 | 40 |
| • Cystic fibrosis | 30 | 15 | 25 |
| • Pulmonary Fibrosis | 20 | 5 | 10 |
| • PHT b | 0 | 0 | 10 |
| • PPH b | 5 | 5 | 0 |
| • Other c | 10 | 25 | 10 |
| Spirometry | |||
| • TLCO | 5.25 (1.49) | 5.08 (2.18) | 3.61 (1.56) |
| • PEF | 7.75 (2.15) | 5.51 (2.06) | 5.01 (1.74) |
| • FEF (25–75) | 2.79 (1.36) | 1.04 (0.83) | 1.17 (0.92) |
| • MIF | 4.55 (1.90) | 3.91 (1.08) | 3.60 (1.26) |
| • FEV1/FVC ratio, % | 82 (9) | 58 (13) | 69 (17) |
| Overall survival, days | 2569 (215) | 1009 (526) | 434 (376) |
a Values are reported in the given units with standard deviation in parentheses. Characteristics and demographic information of recipients is based on the day of bronchoalveolar lavage (BAL) collection. Demographic information of donors is based on the day of lung transplant. b One bronchiolitis obliterans (BOS) patient with PPH was diagnosed with PAH. Two restrictive allograft syndrome (RAS) patients had a PHT diagnosis, one with PAH and one with congenital heart syndrome. One stable patient with PPH was diagnosed with Eisenmenger syndrome. c Other indications included: William Campbell, histiocytosis X, NSIP, UIP, sarcoidosis, asthma, Alpha-1, LAM, and BRECT. BOS, bronchiolitis obliterans. RAS, restrictive allograft syndrome. COPD, chronic obstructive pulmonary disease; PPH, primary pulmonary hypertension; Alpha-1, alpha-1 antitrypsin deficiency; NSIP, nonspecific interstitial pneumonia; UIP, usual interstitial pneumonia; PHT, pulmonary hypertension; LAM, lymphangioleiomyomatosis. BRECT, bronchiectasis; TLCO, transfer factor; PEF, peak expiratory flow; FEF (25–75), forced expiratory flow at 25%–75%; MIF, maximum inspiratory flow.