Figure 1.

Oocytes formed during adult life in mice contribute directly to offspring production. Schematic representation of an inducible genetic lineage-tracing model to ‘mark’ new oocytes formed during the doxycycline (dox) induction phase, which specifically activates a triple-transgenic Cre-loxP–based reporter system tied to stimulated by retinoic acid gene 8 (Stra8) expression in pre-meiotic germ cells (viz. OSCs) committing to meiosis followed by de novo oogenesis. Portions of this figure were adapted with permission from Wang et al. [84].