Figure 2.

Current and potential therapies directed against targets to reduce inflammation and improve intestinal barrier function in patients with inflammatory bowel disease. AMPs = antimicrobial peptides, CRH = corticotrophin releasing hormone, ENS = enteric nervous system, EOS = eosinophil, FMT = fecal microbiota transplantation, GC = goblet cell, JAK = Janus kinases, Mϕ = macrophage MC = mast cell, NEUT = neutrophil NLR = nod-like receptor, OSM = oncostatin M, PC = Paneth cell, SP = substance P, TJs = tight junctions, TLR = toll-like receptor, Treg = regulatory T cell, VIP = vasoactive intestinal polypeptide.