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. 2019 Jan 27;8(2):148. doi: 10.3390/jcm8020148

Figure 5.

Figure 5

CDH11 inhibition suppresses the stem cell-like phenotype of TNBC cells. (A) Images showing tumorsphere size in wild-type cells and their siCDH11 counterparts of varying cell density. Histograms comparing the tumorsphere sizes of wild-type or si-CDH11 (B) MDA-MB-231 and (C) Hs578t. Histograms comparing the number of tumorspheres formed by wild-type or si-CDH11 (D) MDA-MB-231 and (E) Hs578t cells, based on ImageJ quantification. Only tumor spheres ≥40 μm in size were counted. (F) The effect of siCDH11 on the expression Sox2, KLF4, CD44, and c-Myc proteins in MDA-MB-231 and Hs578t cells. (G) Graphical representation of the migration (upper panel) and invasion (lower panel) of MDA-MB-231 and Hs578t cells. Results represent mean ± SD of 3 independent assays in triplicate. * p < 0.05, ** p < 0.01, *** p < 0.001; WT, wild type; NS, not significant; Scale bar: 100 μm.