Table 1. IC50 values for doxorubicin and other drugs in cancer cells.
Cell Lines and Pretreatments | Doxorubicin (nM) | Oxaliplatin (μM) | 5-Fluorouracil (μM) |
---|---|---|---|
SW48-Dox | 45.60 ± 8.02 | 2.21 ± 0.11 | 6.11 ± 0.79 |
TP53-Dox | 599.9 ± 9.87* | 5.30 ± 0.83* | 12.5 ± 1.07* |
SW48/5-FU | 83.60 ± 5.12* | 0.95 ± 0.04 | 7.6 ± 0.85 |
TP53/5-FU | 413 ± 20.8* | 11.8 ± 4.39* | 17.05 ± 0.92* |
WiDr | 740.88 ± 23.96* | 17.8 ± 0.98* | 19.11 ± 0.77* |
METTL3 siRNA | |||
SW48-Dox | 47.03 ± 3.07 | ||
TP53-Dox | 55.27 ± 5.13** | ||
Neplanocin A | |||
SW48-Dox | 35.6 ± 6.1 | 1.09 ± 0.1 | 2.35 ± 0.16 |
TP53-Dox | 51.17 ± 6.21** | 2.02 ± 0.37** | 7.30 ± 1.02** |
WiDr# | 259.79 ± 35.81** | 9.07 ± 1.57** | 7.52 ± 0.57** |
PDMP | |||
SW48-Dox | 43.27 ± 3.74 | 2.05 ± 0.09 | 5.53 ± 0.65 |
TP53-Dox | 49.42 ± 3.84** | 2.04 ± 0.31** | 4.59 ± 0.15** |
WiDr# | 484.60 ± 11.23** | 12.05 ± 1.68** | 13.97 ± 2.73** |