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. Author manuscript; available in PMC: 2019 Mar 8.
Published in final edited form as: Nanotoxicology. 2018 May 11;12(6):539–553. doi: 10.1080/17435390.2018.1465140

Figure 1: AgNP aerosol exposure alters rat lung mRNA expression.

Figure 1:

Sprague Dawley rats (n=5–6 per group) were exposed to control gas (Air) or AgNP Aerosol (4.9 ng/cm2) (NP). Bronchoalveolar lavage was performed and lung tissue was removed for mRNA expression analysis by RNA-SEQ, 1 and 7 days post exposure. PCA analysis (A) and hierarchical clustering (B) were used to visualise patterns of differentially expressed transcripts. The most highly upregulated transcripts by AgNP are displayed as fold over control (C) and ordered according to Day 1 regulation. Pathway analysis of differentially regulated transcripts by AgNP (Day 1 and 7 combined) is displayed as a function of significant association (D).