Fig. 6.

Evolutionary history of the CfERV-Fc1(a) lineage in canids. An approximately-maximum-likelihood phylogeny was reconstructed from an alignment of 157 ERV-Fc LTR sequences. The tree has been midpoint-rooted for display purposes. Asterisks below nodes indicate local support values > 70%. Chromosomal positions are relative to CanFam3.1 coordinates. A color bar is shown at the right to denote element presence as fixed among Canis (dark blue), insertionally polymorphic (light blue), or not genotyped (gray). LTRs belonging to proviruses are indicated along with the chromosomal position with a (5′) or (3′) as appropriate. Clusters of identical LTR haplotypes are indicated with a vertical dashed line. Mispaired proviral LTRs are indicated by a diamond. LTRs from proviruses lacking cognate LTR pairs (i.e., due to truncation of the element) are indicated with a cross. The scale bar shown represents the evolutionary distance in substitutions per site