Fig. 2.
Airway hyper-responsiveness and inflammatory response with co-exposure of OVA-induced asthma and ODE. a, Three hours following i.n. ODE or saline challenge, airway hyper-responsiveness (AHR) to aerosolized methacholine (0/baseline, 3, 6, 12, 24 mg) was measured and line graph represents mean (± SEM) total lung resistance (RL). b, At 4–5 h post ODE or saline i.n. exposure, cellular influx into the bronchoalveolar lavage fluid (BALF) was determined. Bar graph represents mean with standard error bars shown. N = 7–8 mice/group from 2 independent experiments. Statistical significance denoted (*P < 0.05, **P < 0.01, ***P < 0.001) vs. Sal-Sal. Statistical significance denoted (# P < 0.05, ## P < 0.01, ### P < 0.001) as indicated