Figure 5.

Locomotor activity pretask and post-task training after acute cocaine or saline administration. A, D, Before task training, animals exhibited robust ambulation after cocaine exposure compared with saline. However, after training, only rGT-experienced rats (A,B) showed significantly potentiated cocaine-induced locomotor activity. A, C, In contrast, cued rGT-trained animals maintained comparable locomotor activity as before training, indicating a blunted response to cocaine. B, C, Risk-preference did not mitigate the response to cocaine after training, although risk-preferring animals showed blunted cocaine-induced ambulation before task experience. D–F, Saline-induced locomotion remained relatively stable before and after task experience, indicating that the potentiated response seen in rGT-trained animals was unique to cocaine. Data are mean ± SEM.