. 2019 Mar 6;39(10):1842–1854. doi: 10.1523/JNEUROSCI.3477-17.2018

Table 2.

Cued rGT performance during 10 d self-administration period: decision making by individual choice option at day 1 and 10 of cocaine self-administration and additional task measures at day 1 and 10 of cocaine self-administration^a

Behavioral measure	Time point	Cued saline optimal	Cued saline risk-preferring	Cued cocaine optimal	Cued cocaine risk-preferring	Uncued cocaine optimal
P1	Day 1	12.21 ± 9.82	4.28 ± 2.41	10.67 ± 8.93	3.98 ± 1.54	15.85 ± 4.07
P2		76.66 ± 11.58	24.89 ± 9.12	61.07 ± 9.71	15.78 ± 3.13^b	73.08 ± 7.42
P3		7.99 ± 1.66	35.16 ± 11.82	11.02 ± 4.08	45.35 ± 6.15	2.37 ± 1.40
P4		3.15 ± 2.48	35.67 ± 8.89	17.23 ± 7.43	34.89 ± 6.97	8.70 ± 4.69
P1	Day 10	8.54 ± 7.50	0.89 ± 0.81	2.74 ± 1.87	3.45 ± 1.42	9.33 ± 3.94
P2		81.88 ± 9.30	24.36 ± 9.71	70.66 ± 8.62	5.66 ± 2.36^b	80.71 ± 5.58
P3		7.11 ± 0.79	50.18 ± 12.96	13.69 ± 8.44	62.39 ± 7.72	2.86 ± 1.46
P4		2.47 ± 2.18	24.57 ± 7.37	13.42 ± 7.95	28.50 ± 7.18	7.09 ± 4.22
Premature responses	Day 1	6.04 ± 1.48	22.82 ± 7.47	24.04 ± 5.50^b	22.42 ± 4.15^b	18.89 ± 2.29^b
	Day 10	10.18 ± 3.69	20.85 ± 5.33	5.94 ± 1.73^b	16.46 ± 3.67^b	14.30 ± 2.80^b
Trials completed	Day 1	132.20 ± 8.75	67.74 ± 10.25	93.80 ± 10.38	57.34 ± 4.92	90.45 ± 4.76^b
	Day 10	128.80 ± 13.07	69.60 ± 7.06	95.26 ± 13.58	53.09 ± 2.78	52.46 ± 7.21^b
Omitted responses	Day 1	0.40 ± 0.24	0.86 ± 0.46	0.44 ± 0.24	1.56 ± 0.72	2.82 ± 0.70
	Day 10	0.20 ± 0.20	2.57 ± 1.95	2.00 ± 1.02	2.29 ± 0.75	2.22 ± 0.70
Choice latency	Day 1	1.25 ± 0.30	1.93 ± 0.30	1.05 ± 0.22^b	1.45 ± 0.21^b	1.43 ± 0.23^b
	Day 10	1.74 ± 0.45	1.97 ± 0.33	1.80 ± 0.32^b	1.97 ± 0.29^b	2.52 ± 0.34^b
Collect latency	Day 1	1.04 ± 0.06	0.81 ± 0.21	0.69 ± 0.07	0.78 ± 0.11	1.18 ± 0.17
	Day 10	1.03 ± 0.05	0.60 ± 0.08	0.69 ± 0.06	0.62 ± 0.06	1.25 ± 0.21

^aData are mean ± SEM. We detected a significant main effect of session in P2 for cocaine risk-preferring rats (F_(9,117) = 3.693, p < 0.001), which we followed up with a linear contrast (F_(1,13) = 12.010, p = 0.004) to show that responding for the safe option P2 decreased in a linear fashion as cocaine self-administration progressed. No other options displayed significant within-subjects changes over session (i.e., all terms of individual repeated-measures ANOVAs were nonsignificant.

^bSignificant effect across sessions as determined by post hoc tests.