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. 2019 Mar 1;25:1590–1599. doi: 10.12659/MSM.911862

Figure 5.

Figure 5

Methylation-mediated silencing of miR-211 mediated melanoma cell chemosensitivity. (A, B) MiR-211expression was increased with demethylating agent DAC treatment in A375/CDDP and SK-MEL-28/cisplatin (CDDP) cells, U6 was used as a loading control. Values are means ±SEM. (C). Higher EZH2 expression was in A375/CDDP and SK-MEL-28/CDDP cells compared with wildtype cells, while no markedly change in DNMT1. GAPDH served as the loading control. (D). EZH2 was knockdown in A375/CDDP and SK-MEL-28/CDDP cells. (E). Knockdown of EZH2 could increase miR-211 expression. * P<0.05; ** P<0.01.